The Incarnate Word Cardinals football program is the intercollegiate American football team for the University of the Incarnate Word (UIW) located in San Antonio, Texas. The program began in 2009 and originally competed in NCAA Division II as members of the Lone Star Conference. In 2013, the school moved to Division I. For the 2013 season, UIW competed as a member of the Southland Conference for all sports except football. Football competed with an 11-game schedule as an Independent. UIW began playing Southland football in the 2014 season. The team plays its home games at the 6,000 seat Gayle and Tom Benson Stadium.

The University of the Incarnate Word (UIW) is a private, Catholic university with its main campus in San Antonio and Alamo Heights, Texas. Founded in 1881 by the Sisters of Charity of the Incarnate Word, the university's main campus is located on 154 acres (0.6 km2). It is the largest Catholic university in Texas.