The incense trade route was an ancient network of major land and sea trading routes linking the Mediterranean world with eastern and southern sources of incense, spices and other luxury goods, stretching from Mediterranean ports across the Levant and Egypt through Northeastern Africa and Arabia to India and beyond. These routes collectively served as channels for the trading of goods such as Arabian frankincense and myrrh; Indian spices, precious stones, pearls, ebony, silk and fine textiles; and from the Horn of Africa, rare woods, feathers, animal skins, Somali frankincense, gold, and slaves. The incense land trade from South Arabia to the Mediterranean flourished between roughly the 3rd century BC and the 2nd century AD.

A trade route is a logistical network identified as a series of pathways and stoppages used for the commercial transport of cargo. The term can also be used to refer to trade over bodies of water. Allowing goods to reach distant markets, a single trade route contains long-distance arteries, which may further be connected to smaller networks of commercial and noncommercial transportation routes. Among notable trade routes was the Amber Road, which served as a dependable network for long-distance trade. Maritime trade along the Spice Route became prominent during the Middle Ages, when nations resorted to military means for control of this influential route. During the Middle Ages, organizations such as the Hanseatic League, aimed at protecting interests of the merchants and trade became increasingly prominent.