Independence is a town located in and the county seat of Grayson County, Virginia. At the 2020 U.S. census, it had a population of 1,001. It is situated on Virginia's Crooked Road, a heritage trail celebrating the musical heritage of Southwest Virginia.

Grayson County is a county located in the southwestern part of the Commonwealth of Virginia. As of the 2020 census, the population was 15,333. Its county seat is Independence. Mount Rogers, the state's highest peak at 5,729 feet (1,746 m), is in Grayson County.