The Independent Spirit Award for Best Female Lead was one of the annual Independent Spirit Awards to honor an actress who has delivered an outstanding lead performance in an independent film. It was first presented in 1985 with Geraldine Page being the first recipient of the award for her role as Carrie Watts in The Trip to Bountiful. It was last presented in 2022 with Taylour Paige being the final recipient of the award for her role in Zola.

The Trip to Bountiful is a 1985 American road drama film directed by Peter Masterson and starring Geraldine Page, John Heard, Carlin Glynn, Richard Bradford and Rebecca De Mornay. It was adapted by Horton Foote from his 1953 play of the same name. The film features a soundtrack by J.A.C. Redford featuring Will Thompson's "Softly and Tenderly" sung by Cynthia Clawson. Geraldine Page won the Academy Award for Best Actress for her performance as Mrs. Watts and Horton Foote was nominated for the Academy Award for Best Adapted Screenplay.