An index register in a computer's CPU is a processor register used for pointing to operand addresses during the run of a program. It is useful for stepping through strings and arrays. It can also be used for holding loop iterations and counters. In some architectures it is used for read/writing blocks of memory. Depending on the architecture it may be a dedicated index register or a general-purpose register. Some instruction sets allow more than one index register to be used; in that case additional instruction fields may specify which index registers to use.

The Manchester Mark 1 was one of the earliest stored-program computers, developed at the Victoria University of Manchester, England from the Manchester Baby. Work began in August 1948, and the first version was operational by April 1949; a program written to search for Mersenne primes ran error-free for nine hours on the night of 16/17 June 1949.