In molecular biology, BAG domains are protein domains found in proteins which are modulators of chaperone activity, they bind to HSP70/HSC70 proteins and promote substrate release. The proteins have anti-apoptotic activity and increase the anti-cell death function of BCL-2 induced by various stimuli. BAG-1 binds to the serine/threonine kinase Hsc70/Hsp70 in a mutually exclusive interaction. BAG-1 promotes cell growth by binding to and stimulating Raf-1 activity; the binding of Hsp70 to BAG-1 diminishes Raf-1 signalling and inhibits subsequent events, such as DNA synthesis, as well as arrests the cell cycle. BAG-1 has been suggested to function as a molecular switch that encourages cells to proliferate in normal conditions but become quiescent under a stressful environment. BAG-family proteins contain a single BAG domain, except for human BAG-5; the BAG domain is a conserved region located at the C terminus of the BAG-family proteins that binds the ATPase domain of Hsc70/Hsp70. The BAG domain is evolutionarily conserved, BAG domain containing proteins have been described and/or proven in a variety of organisms including Mus musculus, Xenopus spp.
Drosophila spp. Bombyx mori, Caenorhabditis elegans, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Arabidopsis thaliana; the BAG domain has 110-124 amino acids and is composed of three anti-parallel alpha-helices, each 30-40 amino acids in length. The first and second helices interact with the serine/threonine kinase Raf-1 and the second and third helices are the sites of the BAG domain interaction with the ATPase domain of Hsc70/Hsp70. Binding of the BAG domain to the ATPase domain is mediated by both electrostatic and hydrophobic interactions in BAG-1 and is energy requiring
Saint Michael the Archangel High School is an accredited, private, co-educational, Catholic high school located in Fredericksburg, Virginia, USA. The school offers a wide range of honors and AP courses. Saint Michael the Archangel High School takes pride in their religious belief; every Wednesday, Father Peter hosts weekly Mass at the school gym. Each year, all school faculty and students participate in March for Life in Washington, D. C; each student must complete a minimum of 150 service hours in order to graduate from Saint Michael the Archangel High School in keeping with the Gospel teaching that Jesus came to serve not to be served. The school's official website states that students will serve with an attitude of joy and charity as God loves a cheerful giver. Moreover, the school assigns service hour requirements per grade level and increases the hour requirements as students become more accustomed to the academic rigors of high school
Hyla annectans is a species of tree frog in the family Hylidae. It is found in Asia south of the Himalayas in northeast India, northern Myanmar, northern montane Vietnam and southwestern and central China. There are isolated records in adjacent Myanmar. There is uncertainty whether Hyla gongshanensis from China should be recognized as a distinct species; this widespread species has many common names: Jerdon's tree frog, Assam treefrog, Indian hylid frog, green leave frog, or Southwestern China treefrog. The following description is taken from George Albert Boulenger's Fauna of British India, including Ceylon and Burma: The tongue circular nicked, free behind. Vomerine teeth in two groups on a level with the hinder edge of the choanae; the head broader than long. Fingers webbed at the base; the tibiotarsal articulation reaches the eye. Skin smooth above, granular beneath. Green above. Male with an external subgular vocal sac and black nuptial excrescences on the thumb. From snout to vent 2 inches. Modern sources give snout -- vent length 28 -- 39 mm for 32 -- 45 mm for females.
Hyla annectans occurs in tropical evergreen and deciduous forest at elevations of 600–2,500 m above sea level, down to 100 m in India. It can be found in grasslands and agricultural land close to forests, it is arboreal. Breeding takes place in ponds and terraced paddy fields, it is common in parts of its range, notably China. It can be threatened including water pollution, it is collected for in India. The range of this species includes many protected areas
The St. Louis Bombers were an original National Basketball Association franchise based in St. Louis, Missouri. Founded in 1946, the team ceased operations in 1950; the St. Louis Bombers were part of the Basketball Association of America in 1946; the BAA merged with the National Basketball League in 1949 to become the National Basketball Association. The Bombers were one of seven teams that left the NBA: The NBA contracted after the 1949-1950 season, losing six teams: The Anderson Packers, Sheboygan Red Skins and Waterloo Hawks jumped to the NPBL, while the Chicago Stags, Denver Nuggets and St. Louis Bombers folded; the league went from 17 teams to 11. Midway through the 1950-1951 season, the Washington Capitols folded as well, bringing the number of teams in the league down to ten; the NBA would return to St. Louis in 1955. Ed Macauley would end up back in St. Louis in a deal that sent Bill Russell to the Boston Celtics, played a key role in the Hawks 1958 NBA championship; the Bombers played at the St. Louis Arena.
The arena was torn down in 1999. Ed Macauley Inducted, 1960. Ken Loeffler Inducted, 1964 Grady Lewis Johnny Orr Red Rocha The 1948 BAA Playoffs did not establish Eastern and Western champions and generated one finalist from the East, one from the West, only by coincidence. Philadelphia and St. Louis won the Eastern and Western Divisions and met in a best-of-seven series to determine one league championship finalist. Meanwhile, four runners-up played best-of-three matches to determine the other finalist. Baltimore, tied for second in the West, one game behind St. Louis, won that runners-up bracket and defeated Philadelphia in a best-of-seven series to win the BAA championship. St. Louis had achieved the league's best record at 29–19; the 1949 BAA Playoffs matched Eastern teams and Western teams so that the league semifinals generated Eastern and Western champions as well as championship finalists
Najdi Arabic is the group of Arabic varieties originating from the Najd region of Saudi Arabia. As a result of migration, several regions outside of Najd, including Eastern, Al Jawf and Northern Borders Regions are now Najdi-speaking. Outside of Saudi Arabia, it is the main Arabic variety spoken in the Syrian Desert of Iraq and Syria as well as the westernmost part of Kuwait. Najdi Arabic can be divided into four region-based groups: Northern Najdi, spoken in Ha'il Region and Al-Qassim Region in the Najd. Mixed northern-central Najdi of Al-Qassim Central Najdi, spoken in the city of Riyadh and surrounding towns and farming communities. Southern Najdi, spoken in the city of Al-Kharj and surrounding towns, in the Rub' al-Khali. Here is a table of the consonant sounds of Najdi Arabic; the phonemes /p/ ⟨پ⟩ and /v/ ⟨ڤ⟩ are not considered to be part of the phonemic inventory, as they exist only in foreign words and can be pronounced as /b/ and /f/ depending on the speaker. Phonetic notes: /ɡ/ is the modern reflex of Classical /q/ ⟨ق⟩, though /q/ can appear in a few loanwords from Modern Standard Arabic and proper names, as in القرآن and قانون.
The distinction between the Classical Arabic ⟨ﺽ⟩ and ⟨ظ⟩ was lost in Najdi Arabic, both are realised as /ðˤ/. /tˤ/ is sometimes voiced. As in many other the marginal phoneme /ɫ/ only occurs in the word الله /aɫːaːh/ and words derived from it, it contrasts with /l/ in والله /waɫːa/ vs. ولَّا /walːa/, but it occurs as an allophone of /l/ in many other contexts when neighboring the phonemes /ɡ, x, sˤ, tˤ/ e.g. قَلَم /ɡalam/→. The phonemes /ɣ/ ⟨غ⟩ and /x/ ⟨خ⟩ can be realised as uvular fricatives and respectively. Northern and central dialects feature affricates and as allophonic variants of the velar stops /k/ and /ɡ/ particularly in the context of front vowels e.g. كَلْب. Dialect leveling as a result of influence from the Riyadh-based prestige varieties has led to the affricate allophones becoming less common among younger speakers. /ʔ/ was deleted. It now appears only in borrowings from Classical Arabic. Unless adjacent to /ɣ x h ħ ʕ/, /a/ is raised in open syllables to, or, depending on neighboring sounds.
Remaining /a/ may become fronted to in the context of front sounds, as well as adjacent to the pharyngeals /ħ ʕ/. Najdi Arabic exhibits insertion of epenthetic / a / after. For example, >. When short /a/ appears in an open syllable, followed by a nonfinal light syllable, it is deleted. For example, /saħab-at/ is realized as. This, combined with the gahawa syndrome can make underlying sequence of /a/ and a following guttural consonant to appear metathesized, e.g. /ʕistaʕʒal/. Short high vowels are deleted in non-final open syllables, such as /tirsil-uːn/. There is both limited distributional overlap and free variation between and, with the latter being more in the environment of bilabials, pharyngealized consonants, /r/; the mid vowels /eː oː/ are monophthongs, though they can be pronounced as diphthongs when preceding a plosive, e.g. /beːt/. Najdi Arabic sentence structure can have the word order VSO and SVO, however, VSO occurs more often. Ingham NA morphology is distinguished by three categories which are: nouns ism, verb fial, particle harf.
Ism means name in Arabic and it corresponds to nouns and adjectives in English. Fial means action in Arabic and it corresponds to verbs. Harf means letter and corresponds to pronouns, prepositions and articles. Verbs are inflected for number, person, tense and transitives. Nouns shows gender. Complementizers in NA have three different classes which are: relative particle, declarative particle, interrogative particles; the three different complementizers that are used in Najdi Arabic are: illi, in, itha. Two particles are used in negation, which are: la; these particles come before the verb in verbal sentences. Ingham ma is used with all verbal sentences but la is used with imperative verb forms indicating present and future tense. Varieties of Arabic Peninsular Arabic Al-Rojaie, Y. "Regional dialect leveling in Najdi Arabic: The case of the deaffrication of in the Qaṣīmī dialect", Language Variation and Change, 25: 43–63, doi:10.1017/s0954394512000245 Al Motairi, Sarah Soror, An Optimality-Theoretic Analysis of Syllable Structure in Qassimi Arabic Ingham, Bruce, "Notes on the Dialect of the Āl Murra of Eastern and Southern Arabia", Bulletin of the School of Oriental and African Studies, University of London, 49: 271–291, doi:10.1017/s0041977x00024162 Ingham, Najdi Arabic: Central Arabian, Amsterdam: John Benjamins, ISBN 9789027238016 McCarthy, John J. Hidden Generalizations: Phonological Opacity in Optimality Theory, London: Equinox Publishing Ltd.
ISBN 9781845530518 P. F. Abboud. 1964. "The Syntax of Najdi Arabic", University of Texas PhD dissertation. Al-Mozainy, Hamza Q. Vowel Alternations in a Bedouin Hijazi Arabic Dialect: Abstractness and Stress. Austin, Texas: University of Texas, Austin