Indian removals in Indiana followed a series of the land cession treaties made between 1795 and 1846 that led to the removal of most of the native tribes from Indiana. Some of the removals occurred prior to 1830, but most took place between 1830 and 1846. The Lenape (Delaware), Piankashaw, Kickapoo, Wea, and Shawnee were removed in the 1820s and 1830s, but the Potawatomi and Miami removals in the 1830s and 1840s were more gradual and incomplete, and not all of Indiana's Native Americans voluntarily left the state. The most well-known resistance effort in Indiana was the forced removal of Chief Menominee and his Yellow River band of Potawatomi in what became known as the Potawatomi Trail of Death in 1838, in which 859 Potawatomi were removed to Kansas and at least forty died on the journey west. The Miami were the last to be removed from Indiana, but tribal leaders delayed the process until 1846. Many of the Miami were permitted to remain on land allotments guaranteed to them under the Treaty of St. Mary's (1818) and subsequent treaties.

The Kickapoo people are an Algonquian-speaking Native American and Indigenous Mexican tribe, originating in the region south of the Great Lakes. Today, three federally recognized Kickapoo tribes are in the United States: the Kickapoo Tribe in Kansas, the Kickapoo Tribe of Oklahoma, and the Kickapoo Traditional Tribe of Texas. The Oklahoma and Texas bands are politically associated with each other. The Kickapoo in Kansas came from a relocation from southern Missouri in 1832 as a land exchange from their reserve there. Around 3,000 people are enrolled tribal members.