Indigenous peoples in Guyana, Native Guyanese or Amerindian Guyanese are Guyanese people who are of indigenous ancestry. They comprise approximately 9.16% of Guyana's population. Amerindians are credited with the invention of the canoe, as well as Cassava-based dishes and Guyanese pepperpot, the national dish of Guyana. Amerindian languages have also been incorporated in the lexicon of Guyanese Creole.

The Indigenous peoples of South America or South American Indigenous peoples, are the pre-Columbian peoples of South America and their descendants. These peoples contrast with South Americans of European ancestry and those of African descent.