Indo-Guyanese or Indian-Guyanese, are Guyanese nationals of Indian origin who trace their ancestry to India and the wider subcontinent. They are the descendants of indentured servants and settlers who migrated from India beginning in 1838, and continuing during the British Raj.

The Indian indenture system was a system of indentured servitude, by which more than 1.6 million workers from British India were transported to labour in European colonies, as a substitute for slave labor, following the abolition of the trade in the early 19th century. The system expanded after the abolition of slavery in the British Empire in 1833, in the French colonies in 1848, and in the Dutch Empire in 1863. British Indian indentureship lasted till the 1920s. This resulted in the development of a large South Asian diaspora in the Caribbean, Natal, East Africa, Réunion, Mauritius, Sri Lanka, Malaysia, Myanmar, and Fiji, as well as the growth of Indo-Caribbean, Indo-African, Indo-Mauritian, Indo-Fijian, Indo-Malaysian, and Indo-Singaporean populations.