Inner Sanctum Mystery, also known as Inner Sanctum, is a popular old-time radio program that aired from January 7, 1941, to October 5, 1952. It was created by producer Himan Brown and was based on the imprint given to the mystery novels of Simon & Schuster. In all, 526 episodes were broadcast.

Himan Brown, also known as Hi Brown, was an American producer of radio and television programs. Over seven decades, Brown produced and directed more than 30,000 radio shows, for all of the major radio networks and syndication. He worked with such actors as Helen Hayes, Boris Karloff, Peter Lorre, Gregory Peck, Frank Sinatra and Orson Welles.