Interior Alaska is the central region of Alaska's territory, roughly bounded by the Alaska Range to the south and the Brooks Range to the north. It is largely wilderness. Mountains include Denali in the Alaska Range, the Wrangell Mountains, and the Ray Mountains. The native people of the interior are Alaskan Athabaskans. The largest city in the interior is Fairbanks, Alaska's second-largest city, in the Tanana Valley. Other towns include North Pole, just southeast of Fairbanks, Eagle, Tok, Glennallen, Delta Junction, Nenana, Anderson, Healy and Cantwell. The interior region has an estimated population of 113,154.

The Alaskan Athabascans, Alaskan Athapascans or Dena are Alaska Native peoples of the Athabaskan-speaking ethnolinguistic group. They are the original inhabitants of the interior of Alaska.