Interstate 10 (I-10) is a part of the Interstate Highway System that runs from Santa Monica, California, to Jacksonville, Florida. In Alabama, the Interstate Highway runs 66.269 miles (106.650 km) from the Mississippi state line near Grand Bay east to the Florida state line at the Perdido River. I-10 is the primary east–west highway of the Gulf Coast region of Alabama. The highway connects Mobile, the largest city in South Alabama, with Pascagoula, Mississippi, to the west and Pensacola, Florida, to the east. Within the state, the highway connects Mobile and Mobile County with the Baldwin County communities of Daphne and Fairhope. I-10 connects Mobile and Baldwin County by crossing the northern end of Mobile Bay and the southern end of the Mobile-Tensaw River Delta via the George Wallace Tunnel in Mobile and the Jubilee Parkway viaduct system between Mobile and Daphne.

Baldwin County is a county located in the southwestern part of the U.S. state of Alabama, on the Gulf coast. It is one of only two counties in Alabama that border the Gulf of Mexico, along with Mobile County. As of the 2020 census, the population was 231,767, making it the fourth-most populous county in Alabama. The county seat is Bay Minette. The county is named after the founder of the University of Georgia, Senator Abraham Baldwin.