In the U.S. state of Arizona, Interstate 10 (I‑10), the major east–west Interstate Highway in the United States Sun Belt, runs east from California, enters Arizona near the town of Ehrenberg and continues through Phoenix and Tucson and exits at the border with New Mexico near San Simon. The highway also runs through the cities of Casa Grande, Eloy, and Marana. Segments of the highway are referred to as either the Papago Freeway, Inner Loop, or Maricopa Freeway within the Phoenix area and the Pearl Harbor Memorial Highway outside metro Phoenix.

U.S. Route 95 (US 95) is a major U.S. Highway in the American state of Arizona. Starting at the Mexican border in San Luis, US 95 acts as the main highway north through Gadsden, Somerton and Yuma before arriving in Quartzsite. Between Quartzsite and the California border on the Colorado River in Ehrenberg, US 95 runs entirely concurrent with I-10. Part of US 95 between San Luis and Yuma is maintained by local governments instead of the Arizona Department of Transportation, which maintains the remainder of the route.