Interstate 10 (I-10) is a transcontinental Interstate Highway in the United States, stretching from Santa Monica, California, to Jacksonville, Florida. The segment of I-10 in California, also known as the Pearl Harbor Memorial Highway, runs east from Santa Monica through Los Angeles, San Bernardino, and Palm Springs before crossing into the state of Arizona. In the Greater Los Angeles area, it is known as the Santa Monica and San Bernardino freeways, linked by a short concurrency on I-5 at the East Los Angeles Interchange. I-10 also has parts designated as the Rosa Parks and Sonny Bono Memorial freeways. Some parts were also formerly designated as the Christopher Columbus Transcontinental Highway. However, the California State Legislature removed this designation following the passage of a bill on August 31, 2022. I-10 is also known colloquially as "the 10" to Southern California residents (See also California English § Freeways).

The East Los Angeles Interchange is an interchange complex located in Boyle Heights, Los Angeles, approximately 1 mile east of Downtown Los Angeles. With its southern portion handling over 550,000 vehicles per day, it is the busiest freeway interchange in the world. The northern portion, called the San Bernardino Split, is often considered a separate interchange. Four numbered routes converge at the interchange: Interstate 5 (I-5), I-10, U.S. Route 101 (US 101), and State Route 60 (SR 60), but the freeway segments shift alignments and directions.