Route 15, consisting of the contiguous segments of State Route 15 (SR 15) and Interstate 15 (I-15), is a major north–south state highway and Interstate Highway in the U.S. state of California, connecting San Bernardino, Riverside, and San Diego Counties. The route consists of the southernmost 289.24 miles (465.49 km) of I-15, which extends north through Nevada, Arizona, Utah, Idaho, and Montana to the Canada–US border. It is a major thoroughfare for traffic between San Diego and the Inland Empire, as well as between Southern California, Las Vegas, Nevada, and the Intermountain West.

San Bernardino County, officially the County of San Bernardino, is a county located in the southern portion of the U.S. state of California, and is located within the Inland Empire area. As of the 2020 U.S. Census, the population was 2,181,654, making it the fifth-most populous county in California and the 14th-most populous in the United States. The county seat is San Bernardino.