Interstate 15 (I-15) runs north–south in the U.S. state of Utah through the southwestern and central portions of the state, passing through most of the state's population centers, including St. George and those comprising the Wasatch Front: Provo–Orem, Salt Lake City, and Ogden–Clearfield. It is Utah's primary and only north–south interstate highway, as the vast majority of the state's population lives along its corridor; the Logan metropolitan area is the state's only Metropolitan Statistical Area through which I-15 does not pass. In 1998, the Utah State Legislature designated Utah's entire portion of the road as the Veterans Memorial Highway.

St. George is a city in and the county seat of Washington County, Utah, United States. Located in southwestern Utah on the Arizona border, it is the principal city of the St. George Metropolitan Statistical Area (MSA). The city lies in the northeasternmost part of the Mojave Desert, immediately south of the Pine Valley Mountains, which mark the southern boundary of the Great Basin. St. George lies slightly northwest of the Colorado Plateau, which ends at the Hurricane Fault. The city is 118 miles (190 km) northeast of Las Vegas, Nevada, and 300 miles (480 km) south-southwest of Salt Lake City, Utah, on Interstate 15.