Interstate 25 (I-25), also known as the Pan-American Freeway, is a major Interstate Highway in the western United States. It is primarily a north–south highway, serving as the main route through New Mexico, Colorado, and Wyoming. I-25 stretches from I-10 at Las Cruces, New Mexico to I-90 in Buffalo, Wyoming. It passes through or near Albuquerque, New Mexico; Pueblo, Colorado; Colorado Springs, Colorado; Denver, Colorado; Fort Collins, Colorado; and Cheyenne, Wyoming. The I-25 corridor is mainly rural, especially in Wyoming, excluding the Albuquerque metropolitan area and the Front Range urban corridor from Pueblo to Cheyenne.

Interstate 10 (I-10) is the southernmost transcontinental highway in the Interstate Highway System. I-10 is the fourth-longest Interstate in the United States at 2,460.34 miles (3,959.53 km), following I-90, I-80, and I-40. This freeway is part of the originally planned network that was laid out in 1956, and its last section was completed in 1990.