Interstate 264 (I-264) is an Interstate Highway in the US state of Virginia. It serves as the primary east–west highway through the South Hampton Roads region in southeastern Virginia. The route connects the central business districts of Chesapeake, Portsmouth, Norfolk, and Virginia Beach and serves as the most direct link between those cities and the resort beaches along Virginia's Atlantic coast.

South Hampton Roads is a region located in the extreme southeastern portion of Virginia's Tidewater region in the United States with a total population of 1,191,937. It is part of the Virginia Beach-Norfolk-Newport News, VA-NC MSA, which itself has a population of 1,724,876.