Interstate 269 (I-269) is a beltway around the city of Memphis, Tennessee, and its adjacent suburban areas in southwestern Tennessee and northern Mississippi, completed in October 2018. I-269 was planned and built to serve as an outer bypass for the Memphis metropolitan area, funneling through traffic around the metro area while also functioning as a bypass of future I-69, which will run directly through the center of the metro area. I-269 currently connects to its parent route, I-69, at an interchange in Hernando, Mississippi, and will do so again in Millington, Tennessee, in the future.

The Memphis–Clarksdale-Forrest City Combined Statistical Area, TN–MS–AR (CSA) is the commercial and cultural hub of the Mid-South or Ark-Miss-Tenn. The census-defined combined statistical area covers eleven counties in three states, Tennessee, Mississippi, and Arkansas. As of 2020 census, the Memphis metropolitan area had a population of 1,389,905 The Forrest City, Arkansas Micropolitan area was added to the Memphis area in 2012 to form the Memphis–Forrest City Combined Statistical area. In 2023 the Clarksdale, Mississippi Micropolitan area was also added to form the new Memphis-Clarksdale-Forrest City Combined Statistical Area which as of 2023 had a population of roughly 1.4 million people according to census estimates.