Interstate 280 (I-280) is a 12.41-mile-long (19.97 km) auxiliary Interstate Highway in Ohio that connects I-75 in northeast Toledo with I-80/I-90 southeast of the city in northeastern Wood County. Built between 1955 and 1959, the route was originally part of the Detroit–Toledo Expressway. Although first designated in 1959, the highway originally contained several at-grade intersections and other features which left it substandard to the Interstate Highway System until 1990. Further construction in 2007 built a new crossing of the Maumee River, replacing an outdated drawbridge. The highway serves as an easterly bypass of the Toledo metropolitan area, passing through the communities of Northwood and Oregon. It is one of two auxiliary Interstate Highways serving Toledo, the other being I-475.

The Veterans' Glass City Skyway, commonly called the Toledo Skyway Bridge, is a cable-stayed bridge on Interstate 280 in Toledo, Ohio. After many delays, it opened in 2007. The bridge has taken traffic and reduced delays on the Robert Craig Memorial Bridge, a bascule bridge that was, until its transfer to local control, one of the last moveable bridges on the Interstate highway system. The Skyway is Ohio Department of Transportation's (ODOT) biggest single construction project.