Interstate 280 (I-280) is an auxiliary Interstate Highway that makes up the western and southern portions of the beltway around the Quad Cities of Illinois and Iowa. The freeway starts at I-80 near Davenport, Iowa, and ends at I-80 near Colona, Illinois; its eastern part runs concurrent with I-74 to return to I-80. I-280 forms the southern part of a circle around the Quad Cities as well as forming part of a bypass for US Route 61 (US 61) around Davenport. This road is 26.98 miles (43.42 km) long.

The Quad Cities is a region of cities in the U.S. states of Iowa and Illinois: Davenport and Bettendorf in southeastern Iowa, and Rock Island, Moline and East Moline in northwestern Illinois. These cities are the center of the Quad Cities metropolitan area, a region within the Mississippi River Valley, which as of 2023 had a population estimate of 467,817 and a Combined Statistical Area (CSA) population of 474,019, making it the 90th-largest CSA in the nation.