Interstate 29 (I-29) is an Interstate Highway in the Midwestern United States. I-29 runs from Kansas City, Missouri, at a junction with I-35 and I-70, to the Canada–US border near Pembina, North Dakota, where it connects with Manitoba Provincial Trunk Highway 75 (PTH 75), which continues on to Winnipeg. The road follows the course of three major rivers, all of which form the borders of US states. The southern portion of I-29 closely parallels the Missouri River from Kansas City northward to Sioux City, Iowa, where it crosses and then parallels the Big Sioux River. For the northern third of the highway, it closely follows the Red River of the North. The major cities that I-29 connects to includes Council Bluffs, Iowa; Sioux City, Iowa; Sioux Falls, South Dakota; Fargo, North Dakota; and Grand Forks, North Dakota.

Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexican border to Duluth, Minnesota, at Minnesota State Highway 61 and 26th Avenue East. The highway splits into I-35E and I-35W in two separate places, the Dallas–Fort Worth metroplex in Texas and at the Minnesota twin cities of Minneapolis–Saint Paul.