Interstate 35 (I-35) is an Interstate Highway in the US that runs from the Mexican border near Laredo, Texas, to Duluth, Minnesota. In Kansas, the highway goes from the Oklahoma border to Kansas City at the Missouri border, with a length of 235 miles (378 km). Along the way, I-35 passes through Wichita, the state's largest city, linking it to Emporia, Ottawa, and Kansas City and its Johnson County suburbs. The section of the route from the Oklahoma border to I-335 is part of the Kansas Turnpike.

U.S. Route 160 (US-160) is a part of the U.S. Highway System that runs from US-89 near Tuba City, Arizona east to US-67 and Missouri Route 158 southwest of Poplar Bluff, Missouri. In the state of Kansas, US-160 is a main east–west highway that runs from the Colorado border east to the Missouri border.