Interstate 35 (I-35) is a major north–south Interstate Highway that runs from Laredo, Texas near the Mexican border to Duluth, Minnesota. In Texas, the highway begins in Laredo and runs north to the Red River north of Gainesville, where it crosses into Oklahoma. Along its route, it passes through the cities of San Antonio, Austin, and Waco before splitting into two branch routes just north of Hillsboro: I-35E heads northeast through Dallas, while I-35W turns northwest to run through Fort Worth. The two branches rejoin in Denton to again form I-35, which continues to the Oklahoma state line. The exit numbers for I-35E maintain the sequence of exit numbers from the southern segment of I-35, and the northern segment of I-35 follows on from the sequence of exit numbers from I-35E. I-35W maintains its own sequence of exit numbers.

Denton is a city in the U.S. state of Texas and the seat of Denton County. With a population of 139,869 as of 2020, it is the 20th-most populous city in Texas, the 177th-most populous city in the United States, and the 12th-most populous city in the Dallas–Fort Worth metroplex.