Interstate 375 (I-375) is a north–south auxiliary Interstate Highway in Detroit, Michigan, United States. It is the southernmost leg of the Walter P. Chrysler Freeway and a spur of I-75 into Downtown Detroit, ending at the unsigned Business Spur I-375, better known as Jefferson Avenue. The freeway opened on June 12, 1964. At only 1.062 miles (1.709 km) in length, it once had the distinction of being the shortest signed Interstate Highway in the country before I-110 in El Paso, Texas, was signed. The Michigan Department of Transportation (MDOT) announced in 2021 plans to convert the freeway to a boulevard. Details of that project were revealed in April 2023 with MDOT reaffirming that construction is scheduled to begin in 2025.

Interstate 75 (I-75) is a part of the Interstate Highway System that runs north–south from Miami, Florida, to Sault Ste. Marie in the Upper Peninsula of the US state of Michigan. I-75 enters the state from Ohio in the south, north of Toledo, and runs generally northward through Detroit, Pontiac and Bay City, crosses the Mackinac Bridge, and ends at the Canadian border in Sault Ste. Marie. The freeway runs for approximately 396 miles (637 km) on both of Michigan's major peninsulas. The landscapes traversed by I-75 include Southern Michigan farmland, northern forests, suburban bedroom communities, and the urban core of Detroit. The freeway also uses three of the state's monumental bridges to cross major bodies of water. There are four auxiliary Interstates in the state related to I-75, as well as nine current or former business routes, with either Business Loop I-75 or Business Spur I-75 designations.