Interstate 376 (I-376) is a major auxiliary route of the Interstate Highway System in the US state of Pennsylvania, located within the Allegheny Plateau. It runs from I-80 near Sharon south and east to a junction with the Pennsylvania Turnpike in Monroeville, after having crossed the Pennsylvania Turnpike at an interchange in Big Beaver. The route serves Pittsburgh and its surrounding areas and is the main access road to Pittsburgh International Airport (PIT). Portions of the route are known as the Beaver Valley Expressway, Southern Expressway, and Airport Parkway. Within Allegheny County, the route runs along the majority of the Penn-Lincoln Parkway, known locally as Parkway West and Parkway East. It is currently the ninth-longest auxiliary Interstate route in the system and second only to I-476 within Pennsylvania.

Interstate 80 (I-80) in the US state of Pennsylvania runs for 311.12 miles (500.70 km) across the central part of the state. It is designated as the Keystone Shortway and officially as the Z.H. Confair Memorial Highway. This route was built mainly along a completely new alignment, not paralleling any earlier US Routes, as a shortcut to the tolled Pennsylvania Turnpike to the south and New York State Thruway to the north. It does not serve any major cities in Pennsylvania and is mainly a cross-state route on the Ohio–New York City corridor. Most of I-80's path across the state goes through hilly and mountainous terrain, while the route passes through relatively flat areas toward the western part of the state.