Interstate 395 (I-395) is an auxiliary Interstate Highway in the U.S. states of Connecticut and Massachusetts; it is maintained by the Connecticut Department of Transportation (CTDOT) and the Massachusetts Department of Transportation (MassDOT). Spanning nearly 67 miles (108 km) on a south–north axis, it is the only spur route of I-95 in Connecticut. The 36-mile (58 km) section between its splits from I-95 in East Lyme and SR 695 in Plainfield is a component highway of the Connecticut Turnpike. Within that state, the highway is named the American Ex-Prisoner of War Memorial Highway from Plainfield to Thompson.

Interstate 95 (I-95) is the main north–south Interstate Highway on the East Coast of the United States, running in a general east–west compass direction for 111.57 miles (179.55 km) in Connecticut, from the New York state line to the Rhode Island state line. I-95 from Greenwich to East Lyme is part of the Connecticut Turnpike, during which it passes through the major cities of Stamford, Bridgeport, and New Haven. After leaving the turnpike in East Lyme, I-95 is known as the Jewish War Veterans Memorial Highway and passes through New London, Groton, and Mystic, before exiting the state through North Stonington at the Rhode Island border.