Interstate 395 (I-395) is an auxiliary Interstate Highway in the US state of Maryland. Known as Cal Ripken Way, the highway runs 1.98 miles (3.19 km) from I-95 north to Howard Street and Camden Street in Downtown Baltimore, where it provides access to the Inner Harbor and the Baltimore Convention Center. The Interstate also serves the Camden Yards Sports Complex, which contains M&T Bank Stadium and Oriole Park at Camden Yards, homes of the Baltimore Ravens and Baltimore Orioles, respectively. I-395 also serves as the southern terminus of Martin Luther King Jr. Boulevard, an urban arterial that provides a western bypass of Downtown Baltimore and connects I-95 with U.S. Route 40 (US 40), US 1, and I-83. The Interstate is maintained by the Maryland Transportation Authority (MDTA) and, like all Interstates, is a part of the National Highway System.

Interstate 95 (I-95) is an Interstate Highway running along the East Coast of the United States from Miami, Florida, north to the Canada–United States border at Houlton, Maine. In Maryland, the route is a major highway that runs 110.01 miles (177.04 km) diagonally from southwest to northeast, entering from the District of Columbia and Virginia at the Woodrow Wilson Bridge over the Potomac River, northeast to Maryland's border with Delaware near Elkton. It is the longest Interstate Highway within Maryland and is one of the most traveled Interstate Highways in the state, especially between Baltimore and Washington, D.C., despite alternate routes along the corridor, such as the Baltimore–Washington Parkway, U.S. Route 1 (US 1), and US 29. I-95 also has eight auxiliary routes in the state, the most of any state along the I-95 corridor. Portions of the highway, including the Fort McHenry Tunnel and the Millard E. Tydings Memorial Bridge, are tolled.