Interstate 95 (I-95) is an Interstate Highway running along the East Coast of the United States from Miami, Florida, north to the Canada–United States border at Houlton, Maine. In Maryland, the route is a major highway that runs 110.01 miles (177.04 km) diagonally from southwest to northeast, entering from the District of Columbia and Virginia at the Woodrow Wilson Bridge over the Potomac River, northeast to Maryland's border with Delaware near Elkton. It is the longest Interstate Highway within Maryland and is one of the most traveled Interstate Highways in the state, especially between Baltimore and Washington, D.C., despite alternate routes along the corridor, such as the Baltimore–Washington Parkway, U.S. Route 1 (US 1), and US 29. I-95 also has eight auxiliary routes in the state, the most of any state along the I-95 corridor. Portions of the highway, including the Fort McHenry Tunnel and the Millard E. Tydings Memorial Bridge, are tolled.

Maryland is a state in the Mid-Atlantic region of the United States. The state borders Virginia to its south, West Virginia to its west, Pennsylvania to its north, Delaware to its east, the Atlantic Ocean, and the national capital of Washington, D.C. With a total area of 12,407 square miles (32,130 km2), Maryland is the ninth-smallest state by land area, and its population of 6,177,224 ranks it the 18th-most populous state and the fifth-most densely populated. Maryland's capital is Annapolis, and the most populous city is Baltimore. Occasional nicknames include Old Line State, the Free State, and the Chesapeake Bay State. It is named after Henrietta Maria, the French-born queen of England, Scotland, and Ireland during the 17th century.