Interstate 4 (I-4) is an Interstate Highway located entirely within the US state of Florida, maintained by the Florida Department of Transportation (FDOT). Spanning 132.30 miles (212.92 km) along a generally southwest–northeast axis, I-4 is entirely concurrent with State Road 400 (SR 400). In the west, I-4 begins at an interchange with I-275 in Tampa. I-4 intersects with several major expressways as it traverses Central Florida, including US Highway 41 (US 41) in Tampa; US 301 near Riverview; I-75 near Brandon; US 98 in Lakeland; US 27 in unincorporated Davenport; US 192 in Celebration; Florida's Turnpike in Orlando; and US 17 and US 92 in multiple junctions. In the east, I-4 ends at an interchange with I-95 in Daytona Beach, while SR 400 continues for roughly another four miles (6.4 km) and ends at an intersection with US 1 on the city line of Daytona Beach and South Daytona.

Interstate 275 (I-275), located in Florida, is a 60-mile-long (97 km) auxiliary Interstate Highway serving the Tampa Bay area. Its southern terminus is at I-75 near Palmetto, where I-275 heads west towards the Sunshine Skyway Bridge crossing over Tampa Bay. From that point, I-275 passes through St. Petersburg before crossing Tampa Bay again on the Howard Frankland Bridge, then continues through the city of Tampa, where it connects to an interchange with I-4 in Downtown Tampa. After the interchange, I-275 passes north through the Tampa suburbs to its northern terminus at I-75 in Wesley Chapel.