Interstate 40 (I-40) is a major east–west Interstate Highway in the United States, stretching from Barstow, California, to Wilmington, North Carolina. The segment of I-40 in California is sometimes called the Needles Freeway. It passes through the eastern fringe of the Inland Empire metropolitan area, going east from its western terminus at I-15 in Barstow across the Mojave Desert in San Bernardino County past the Clipper Mountains to Needles, before it crosses over the Colorado River into Arizona east of Needles. All 155 miles (249 km) of I-40 in California are in San Bernardino County.

Barstow is a city in San Bernardino County, California, in the Mojave Desert of Southern California. Located in the Inland Empire region of California, the population was 25,415 at the 2020 census. Barstow is an important crossroads for the Inland Empire and home to Marine Corps Logistics Base Barstow.