Interstate 40 (I-40) is a part of the Interstate Highway System that travels 2,556.61 miles (4,114.46 km) from Barstow, California, to Wilmington, North Carolina. In North Carolina, I-40 travels 420.21 miles (676.26 km) across the entirety of the state from the Tennessee state line along the Pigeon River Gorge to U.S. Highway 117 (US 117) and North Carolina Highway 132 (NC 132) in Wilmington. I-40 is the longest Interstate Highway in North Carolina and is the only Interstate to completely span the state from west to east.

Interstate 140 (I-140) and North Carolina Highway 140 (NC 140) is a 25.4-mile (40.9 km) auxiliary Interstate Highway and state highway in the U.S. state of North Carolina. Officially designated the John Jay Burney Jr. Freeway, it serves as a bypass of Wilmington. The western terminus of the highway is at U.S. Route 17 (US 17) near Winnabow. It heads north in western Leland before turning to the east north of an interchange with U.S. Route 74 (US 74)/U.S. Route 76 (US 76). I-140 crosses the Cape Fear River north of Navassa and the Northeast Cape Fear River northwest of Wrightsboro. I-140 ends at Interstate 40 (I-40), and the route number changes to NC 140. NC 140 continues to the east, ending at US 17 in Kirkland.