Interstate 49 (I-49) is an Interstate Highway in the US state of Missouri that was designated on December 12, 2012. It overlaps U.S. Route 71 (US 71) in the western part of the state, beginning at the Arkansas state line, and ending at I-435 and I-470 on the southeast side of Kansas City.

U.S. Route 71 (US 71) is a major north–south U.S. Highway that runs from Louisiana to Canada. US 71 enters Missouri from Arkansas in the town of Jane. US 71 serves the cities of Joplin, Kansas City and St. Joseph. At noon on December 12, 2012, the section of US 71 between Pineville, Missouri and I-435 in south Kansas City was also designated as a northern extension of Interstate 49 (I-49).