Interstate 610 (I-610) is an auxiliary Interstate Highway that forms a 37.972-mile-long (61.110 km) loop around the inner city sector of the city of Houston, Texas. I-610, colloquially known as The Loop, Loop 610, The Inner Loop, or just 610, traditionally marks the border between the inner city of Houston and its surrounding areas. It is the innermost of the three Houston beltways, the other two being Beltway 8 and State Highway 99, of which various segments are under construction or planning. In Houston, the area inside I-610 is the urban core. Jeff Balke of the Houston Press wrote that the freeway "is as much a social and philosophical divide as a physical one". Mike Snyder in the Houston Chronicle wrote that, as someone from inside I-610, he historically felt "kind of special" due to being close to "the city's historical core and its major business, educational and cultural institutions".

Houston is the most populous city in the U.S. state of Texas and in the Southern United States. Located in Southeast Texas near Galveston Bay and the Gulf of Mexico, it is the seat and largest city of Harris County; as well as the principal city of the Greater Houston metropolitan area, which is the fifth-most populous metropolitan statistical area in the United States and the second-most populous in Texas after Dallas–Fort Worth. With a population of 2,302,878 in 2022, Houston is the fourth-most populous city in the United States after New York City, Los Angeles, and Chicago, and the seventh-most populous city in North America. Houston is the southeast anchor of the greater megaregion known as the Texas Triangle.