Interstate 64 (I-64) is an east–west Interstate Highway in the Eastern United States. Its western terminus is at I-70, U.S. Route 40 (US 40), and US 61 in Wentzville, Missouri. Its eastern terminus is at the Bowers Hill Interchange with I-264 and I-664 at Bower's Hill in Chesapeake, Virginia. I-64 connects Greater St. Louis, the Louisville metropolitan area, the Lexington–Fayette metropolitan area, the Charleston metropolitan area, the Greater Richmond Region, and Hampton Roads.

Interstate 70 (I-70) is a major east–west Interstate Highway in the United States that runs from I-15 near Cove Fort, Utah, to I-695 and Maryland Route 570 (MD 570) in Woodlawn, just outside Baltimore, Maryland. I-70 approximately traces the path of U.S. Route 40 east of the Rocky Mountains. West of the Rocky Mountains, the route of I-70 was derived from multiple sources. The Interstate runs through or near many major cities, including Denver, Topeka, Kansas City, St. Louis, Indianapolis, Columbus, Pittsburgh, and Baltimore. The sections of the Interstate in Missouri and Kansas have laid claim to be the first Interstate in the United States. The Federal Highway Administration (FHWA) has claimed the section of I-70 through Glenwood Canyon in Colorado, completed in 1992, to be the last piece of the Interstate Highway System, as originally planned, to open to traffic. The construction of I-70 in Colorado and Utah is considered an engineering marvel, as the route passes through the Eisenhower Tunnel, Glenwood Canyon, and the San Rafael Swell. The Eisenhower Tunnel is the highest point along the Interstate Highway System, with an elevation of 11,158 feet (3,401 m).