Interstate 64 (I-64) in the US state of Indiana is a major east–west highway providing access between Illinois and Kentucky. It passes through southern Indiana as part of its connection between the two metropolitan areas of St Louis, Missouri, and Louisville, Kentucky.

Posey County is the southernmost, southwesternmost, and westernmost county in the U.S. state of Indiana. Its southern border is formed by the Ohio River, and its western border by the Wabash River, a tributary to the Ohio. As of 2020, the population was 25,222. The county seat is Mount Vernon.