Interstate 65 (I-65) is a major north–south Interstate Highway in the central United States. As with most primary Interstates ending in 5, it is a major crosscountry, north–south route, connecting between the Great Lakes and the Gulf of Mexico. Its southern terminus is located at an interchange with I-10 in Mobile, Alabama, and its northern terminus is at an interchange with US 12 (US 12) and US 20 in Gary, Indiana, just southeast of Chicago. I-65 connects several major metropolitan areas in the Midwest and Southern US. It connects the four largest cities in Alabama: Mobile, Montgomery, Birmingham, and Huntsville. It also serves as one of the main north–south routes through Nashville, Tennessee; Louisville, Kentucky; and Indianapolis, Indiana, each a major metropolitan area in its respective state.

Interstate 10 (I-10) is the southernmost transcontinental highway in the Interstate Highway System. I-10 is the fourth-longest Interstate in the United States at 2,460.34 miles (3,959.53 km), following I-90, I-80, and I-40. This freeway is part of the originally planned network that was laid out in 1956, and its last section was completed in 1990.