Interstate 65 (I-65) meanders across 366 miles (589 km) of the Alabama countryside linking six of the state's 10 largest cities. The highway links together many important roadways that make commerce inside and outside of the state's boundaries possible. It starts at I-10 near Mobile. The route passes through the major cities of Montgomery, Birmingham, Decatur, Huntsville, and Athens before entering Tennessee in the north near the town of Ardmore, Alabama.

Greenville is a city and the county seat of Butler County, Alabama, United States. At the 2020 census, the population was 7,374. Greenville is known as the Camellia City, wherein originated the movement to change the official Alabama state flower from the goldenrod to the camellia with legislative sponsors LaMont Glass and H.B. Taylor.