Interstate 65 (I-65) enters the US state of Kentucky from Tennessee, five miles (8.0 km) south of Franklin. It passes by the major cities of Bowling Green, Elizabethtown, and Louisville before exiting the state into Indiana.

The Wendell H. Ford Western Kentucky Parkway is a 98.5-mile (158.5 km) freeway running from Elizabethtown, Kentucky to near Nortonville, Kentucky. It intersects with Interstate 65 (I-65) at its eastern terminus, and I-69 at its western terminus. It is one of seven highways that are part of the Kentucky parkway system. The road was renamed for Wendell H. Ford, a former Kentucky governor and United States senator, in 1998. Previously, it was simply the Western Kentucky Parkway, and often called the "WK Parkway" or "the WK" because of the acronym once used on its signs. The parkway carries the unsigned designation Kentucky Route 9001 for its entire length.