Interstate 69 (I-69) in the US state of Kentucky is a 148.1-mile-long (238.3 km) freeway running from Fulton to Henderson. The route makes use of most of the Purchase Parkway and existing portions of I-24, the Western Kentucky Parkway, and the Pennyrile Parkway. Eventually, I-69 will leave the former Pennyrile Parkway just south of the Audubon Parkway interchange or remain on its current alignment and travel through Henderson on U.S. Route 41 (US 41) north into Indiana. The proposed route for the remainder of I-69 in Kentucky travels about 10 miles (16 km) before exiting on a bridge across the Ohio River to Indiana. As of April 2024, it is in early stages of development

Henderson is a home rule-class city along the Ohio River and the county seat of Henderson County, Kentucky, United States. The population was 29,781 at the 2020 U.S. census. It is part of the Evansville–Henderson, IN–KY Metropolitan Area, locally known as the "Tri-State Area," and is considered the southernmost suburb of Evansville, Indiana.