Interstate 70 (I-70) is a part of the Interstate Highway System that runs from Cove Fort, Utah, to Woodlawn just outside of Baltimore, Maryland. In Maryland, the Interstate Highway runs 91.85 miles (147.82 km) from the Pennsylvania state line in Hancock east to the Interstate's eastern terminus at its junction with I-695. I-70 is the primary east–west Interstate in Maryland; the Interstate Highway connects Baltimore—and Washington, D.C., via I-270—with Western Maryland. The Interstate serves Frederick and Hagerstown directly and provides access to Cumberland via its junction with I-68 at Hancock. I-70 runs concurrently with its predecessor highway, U.S. Route 40 (US 40), from Hancock to Indian Springs in Washington County and from Frederick to West Friendship in Howard County.

Hancock is a town in Washington County, Maryland, United States. The population was 1,557 at the 2020 census. The Western Maryland community is notable for being located at the narrowest part of the state. The north–south distance from the Pennsylvania state line to the West Virginia state line is only 1.8 miles (2.9 km) at Hancock.