Interstate 76 (I-76) is an east–west Interstate Highway in the Western United States that runs from I-70 in Arvada, Colorado – near Denver – to an interchange with I-80 near Big Springs, Nebraska. The highway measures 187.29 miles (301.41 km) long, mostly situated in Colorado but approximately three miles (4.8 km) of which is in Nebraska. Along the route, the highway runs concurrent with US Route 6 (US 6), US 85 in the Denver metropolitan area, and US 34 from Wiggins to Fort Morgan. It has no auxiliary Interstates, but it has two business routes that are located in northeastern Colorado. This route is not connected with the other I-76 that spans from Ohio to New Jersey.

Interstate 76 (I-76) is an east–west Interstate Highway in the Eastern United States. The highway runs approximately 435.66 miles (701.13 km) from an interchange with I-71 west of Akron, Ohio, east to I-295 in Bellmawr, New Jersey. This route is not contiguous with I-76 in Colorado and Nebraska.