Interstate 77 (I-77) is a north–south Interstate Highway, extending 91.2 miles (146.8 km) in the state of South Carolina, from the southern terminus at an interchange with I-26 near Columbia, north to the North Carolina state line near Rock Hill and Charlotte, North Carolina.

Interstate 26 (I-26) is a South Carolina Interstate highway running generally east–west from near Landrum, in Spartanburg County, to U.S. Route 17 (US 17), in Charleston, South Carolina. It is also the longest Interstate Highway in South Carolina.