Interstate 80 (I-80) is a transcontinental Interstate Highway in the United States, stretching from San Francisco, California, to Teaneck, New Jersey. In Iowa, the highway travels west to east through the center of the state. It enters the state at the Missouri River in Council Bluffs and heads east through the southern Iowa drift plain. In the Des Moines metropolitan area, I-80 meets up with I-35 and the two routes bypass Des Moines together. On the northern side of Des Moines, the Interstates split and I-80 continues east. In eastern Iowa, it provides access to the University of Iowa in Iowa City. Northwest of the Quad Cities in Walcott is Iowa 80, the world's largest truck stop. I-80 passes along the northern edge of Davenport and Bettendorf and leaves Iowa via the Fred Schwengel Memorial Bridge over the Mississippi River into Illinois.

The local–express lane system is an arrangement of carriageways within a major highway where long distance traffic can use inner express lanes with fewer interchanges compared to local traffic which use outer local lanes that have access to all interchanges. This can also be called a collector/distributor lane system within a single interchange. One of the longest examples is Highway 401 in Toronto, where highway ramps between express and local lanes cross over one another; these are commonly known as braided ramps.