Interstate 80 (I-80) in the US state of Pennsylvania runs for 311.12 miles (500.70 km) across the central part of the state. It is designated as the Keystone Shortway and officially as the Z.H. Confair Memorial Highway. This route was built mainly along a completely new alignment, not paralleling any earlier US Routes, as a shortcut to the tolled Pennsylvania Turnpike to the south and New York State Thruway to the north. It does not serve any major cities in Pennsylvania and is mainly a cross-state route on the Ohio–New York City corridor. Most of I-80's path across the state goes through hilly and mountainous terrain, while the route passes through relatively flat areas toward the western part of the state.

Bloomsburg is a town and the county seat of Columbia County, Pennsylvania, United States. It is part of Northeastern Pennsylvania and is located 40 miles (64 km) southwest of Wilkes-Barre along the Susquehanna River. It is the only Pennsylvania municipality incorporated as a town. As of the 2010 census, Bloomsburg had a population of 14,855, with an estimated population of 13,811 in 2019.