Interstate 85 (I-85) is a major Interstate Highway in the Southeastern United States. Its southern terminus is at an interchange with I-65 in Montgomery, Alabama; its northern terminus is an interchange with I-95 in Petersburg, Virginia, near Richmond. It is nominally north–south as it carries an odd number, but it is physically oriented northeast–southwest and covers a larger east–west span than north–south. While most Interstates that end in a "5" are cross-country, I-85 is primarily a regional route serving five southeastern states: Virginia, North Carolina, South Carolina, Georgia, and Alabama.

The Southeastern United States, also referred to as the American Southeast, the Southeast, or the South, is a geographical region of the United States located in the eastern portion of the Southern United States and the southern portion of the Eastern United States. The region includes a core of states that reaches north to Maryland and West Virginia, bordering the Ohio River and Mason–Dixon line, and stretches west to Arkansas and Louisiana.