Interstate 85 (I-85) in the U.S. state of South Carolina runs northeast–southwest through Upstate South Carolina. Connecting regionally with Atlanta, Georgia, and Charlotte, North Carolina, it became the first Interstate Highway in South Carolina to have its originally planned mileage completed.

South Carolina Highway 11 (SC 11), also known as the Cherokee Foothills Scenic Highway, is a 119.850-mile (192.880 km) state highway through the far northern part of the U.S. state of South Carolina, following the southernmost peaks of the Blue Ridge Mountains. The route is surrounded by peach orchards, quaint villages, and parks. It is an alternative to Interstate 85 (I-85) and has been featured by such publications as National Geographic, Rand McNally, and Southern Living.