Interstate 85 (I-85) in the U.S. state of South Carolina runs northeast–southwest through Upstate South Carolina. Connecting regionally with Atlanta, Georgia, and Charlotte, North Carolina, it became the first Interstate Highway in South Carolina to have its originally planned mileage completed.

The Upstate, historically known as the Upcountry, is a region of the U.S. state of South Carolina, comprising the northwesternmost area of the state. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville-Spartanburg-Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget (OMB) in 2015. In 2023, the OMB issued its most updated definition of the CSA that coincides again with the 10-county region.