Interstate 88 (I-88) is an Interstate Highway located entirely within the US state of New York. Nominally signed as an east–west road as it has an even number, it extends for 117.75 miles (189.50 km) in a northeast–southwest direction from an interchange with I-81 north of the city of Binghamton to an interchange with the New York State Thruway (I-90) west of Schenectady. The freeway serves as an important connector route from the Capital District to Binghamton, Elmira, and Scranton, Pennsylvania. I-88 closely parallels NY 7, which was once the main route through the area.

Interstate 81 (I-81) is a part of the Interstate Highway System that runs from I-40 at Dandridge, Tennessee, to the Thousand Islands Bridge at Wellesley Island in New York, beyond which the short 2.7-mile (4.3 km) Ontario Highway 137 (Highway 137) links it to Highway 401. In the US state of New York, I-81 extends 183.60 miles (295.48 km) from the Pennsylvania state line southeast of Binghamton to the Canadian border at Wellesley Island northwest of Alexandria Bay. The freeway runs north–south through Central New York, serving the cities of Binghamton, Syracuse, and Watertown. It passes through the Thousand Islands in its final miles and crosses two bridges, both part of the series of bridges known as the Thousand Islands Bridge.