Interstate 94 (I-94) runs east–west through the western, central, and southeastern portions of the US state of Wisconsin. A total of 348.23 miles (560.42 km) of I-94 lie in the state.

U.S. Highway 12 in the U.S. state of Wisconsin runs east–west across the western to southeast portions of the state. It enters from Minnesota running concurrently with Interstate 94 (I-94) at Hudson, parallels the Interstate to Wisconsin Dells, and provides local access to cities such as Menomonie, Eau Claire, Black River Falls, Tomah, and Mauston. It then provides an alternative route for traffic between northwestern Wisconsin and Madison and is the anchor route for the Beltline Highway around Madison. Finally, it serves southeastern Wisconsin, connecting Madison with Fort Atkinson, Whitewater, Elkhorn, and Lake Geneva. The West Beltline Highway and the segment between Elkhorn and Genoa City are freeways, and the segment between Sauk City and Middleton is an expressway. The remainder of the road is a two-lane surface road or an urban multilane arterial. Between Hudson and west of Warrens, the road closely parallels the former main line of the Chicago, St. Paul, Minneapolis and Omaha Railway, now operated by Union Pacific Railroad.