Interstate 95 Business is a business loop of I-95 entirely within Cumberland County, North Carolina. It runs from nearby Hope Mills to Eastover, passing through the eastern side of downtown Fayetteville.

Interstate 95 (I-95) is a part of the Interstate Highway System that runs along the East Coast of the United States from Miami, Florida, to the Canada–United States border at Houlton, Maine. In the state of North Carolina, the route runs for 181.36 miles (291.87 km) from the South Carolina border near Rowland to the Virginia border near Pleasant Hill. The highway serves the cities of Lumberton, Fayetteville, Wilson, Rocky Mount, and Roanoke Rapids. The route goes through a mostly rural area of the state, avoiding most of the major metro areas of North Carolina. It forms the informal border between the Piedmont and Atlantic Plain regions of the state.